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Product Information
Description |
p38 rabbit polyclonal |
Protein full name |
Mitogen-activated protein kinase 14 |
Synonyms |
Mitogen-activated protein kinase p38 alpha, MAP kinase 14, CRK1, Mapk14, MAP kinase p38 alpha, Crk1, Csbp1, Csbp2 |
Immunogen |
Recombinant protein corresponding to Mouse p38 |
Isotype |
IgG |
Purity |
Affinity purification |
Subcellular location |
Nucleus, Cytoplasm |
Uniprot ID |
P47811 |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
IHC |
Mouse, Rat |
1: 1500-1: 3000 |
skeletal muscle, placenta, heart |
IF |
Mouse, Rat |
1: 750-1: 2000 |
skeletal muscle, placenta, heart |
Background
P38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a cascade controlling cellular responses to cytokines and stress. Like the SAPK/JNK pathway, P38 MAP kinase is activated by a variety of cellular stresses including inflammatory cytokines, UV light and growth factors, etc. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase-2 and to phosphorylate the transcription factors ATF-2 and Max.
Images
|
Immunohistochemistry analysis of paraffin-embedded mouse skeletal muscle using p38at dilution of 1: 3000 |
|
Immunohistochemistry analysis of paraffin-embedded mouse placenta using p38 at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded mouse heart using p38 at dilution of 1: 3000 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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