Inactivation
of tumor suppressor genes is a key component of the development of all
common forms of human cancers. Aberrant methylation may contribute to
many of the changes, both physiological and pathological, associated
with aging, including tumor development. Hypermethylation of CpG
island-containing promoters is associated with the inactivation of genes
important to tumor angiogenesis and progression. DNA methytransferase
(DNMT3a) is necessary for the maintenance of the methylation process.
Images
Immunohistochemistry of paraffin embedded mouse embryonic mouse using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens)
Immunohistochemistry of paraffin embedded mouse placenta using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens)
Immunohistochemistry of paraffin embedded mouse spleen using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens)
Immunohistochemistry of paraffin embedded mouse testis using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens)
Immunohistochemistry of paraffin embedded rat colon using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens)
Immunohistochemistry of paraffin embedded rat placenta using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens)
Immunohistochemistry of paraffin embedded rat spleen using Dnmt3a (GB111355) at dilution of 1:3200 (400x lens)
Immunofluorescence of paraffin embedded mouse kidney using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens)
Immunofluorescence of paraffin embedded mouse placenta using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens)
Immunofluorescence of paraffin embedded mouse testis using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens)
Immunofluorescence of paraffin embedded rat embryonic rat using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens)
Immunofluorescence of paraffin embedded rat lymph node using Dnmt3a (GB111355) at dilution of 1:1600 (400x lens)
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).