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Product Information
Description |
SUV39H2 rabbit polyclonal antibody |
Protein full name |
Histone-lysine N-methyltransferase SUV39H2 |
Synonyms |
Histone H3-K9 methyltransferase 2, KMT1B, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2, Su(var)3-9 homolog 2, SUV39H2 |
Immunogen |
Recombinant protein corresponding to Mouse SUV39H2 |
Isotype |
IgG |
Purity |
Affinity purification |
Subcellular location |
Nucleus |
Uniprot ID |
Q9H5I1 |
Applications
Applications |
Species |
Dilution |
Positive Sample |
IHC/IF |
Human, Mouse, Rat |
1: 500-1: 4000 |
breast cancer, hippocampus, testis |
Background
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.
Images
Immunohistochemistry of paraffin embedded human breast cancer using Suv39h2 (GB111054) at dilution of 1:2000 (400x lens) | |
Immunofluorescence of paraffin embedded human breast cancer using Suv39h2 (GB111054) at dilution of 1:2000 (400x lens) | |
Immunofluorescence of paraffin embedded mouse hippocampus using Suv39h2 (GB111054) at dilution of 1:2000 (400x lens) | |
|
Immunofluorescence of paraffin embedded rat testis using Suv39h2 (GB111054) at dilution of 1:2000 (400x lens) |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).
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