Anti -RNF8 Rabbit pAb

價格：在線咨詢

貨號：

KT011941

產品規(guī)格：

100ul

Applications：

Species：

M/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	RNF8 rabbit polyclonal antibody
Protein full name	E3 ubiquitin-protein ligase RNF8
Synonyms	ActA-interacting protein 37, AIP37, LaXp180, RING finger protein 8, Rnf8, RING-type E3 ubiquitin transferase RNF8
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse RNF8
Isotype	IgG
Purity	Affinity purification
Predicted MW.	56 kDa
Observed MW.	56 kDa
Uniprot ID	Q8VC56, Q4KLN8

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse, Rat	1: 500-1: 1000	brain

Background

The RNF8 (also named as KIAA0646 or E3 ubiquitin-protein ligase RNF8) contains one RING-type zinc finger and one FHA domain. RNF8 localizes in the nucleus and belongs to the RNF8 family. E2-E3 ubiquitin ligase complex is composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.

Images

Western blot analysis of RNF8 (GB111158) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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