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Product Information
Description |
LAMTOR2 rabbit polyclonal |
Protein full name |
Ragulator complex protein LAMTOR2 |
Synonyms |
Lamtor2, ENDAP, Endosomal adaptor protein p14, MAPBPIP, MAPKSP1AP, P14, ROBLD 3 |
Immunogen |
Recombinant protein corresponding to Mouse LAMTOR2 |
Isotype |
IgG |
Purity |
Affinity purification |
Subcellular location |
Cytoplasm |
Uniprot ID |
Q9JHS3 |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
IHC |
Mouse, Rat |
1: 500-1: 2500 |
brain, lung, stomach |
IF |
Mouse, Rat |
1: 250-1: 500 |
brain, lung, stomach |
Background
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.
Images
Immunohistochemistry analysis of paraffin-embedded mouse brain using LAMTOR2 (GB11935) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using LAMTOR2 (GB11935) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using LAMTOR2 (GB11935) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat lung using LAMTOR2 (GB11935) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded mouse stomach using LAMTOR2 (GB11935) at dilution of 1: 1500 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).
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