Anti -Constitutive androstane receptor Rabbit pAb

價格：在線咨詢

貨號：

KT012075

產(chǎn)品規(guī)格：

100ul

Applications：

WB|IHC/IF

Species：

M/R,M/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Nr1i3 rabbit polyclonal antibody
Protein full name	Nuclear receptor subfamily 1 group I member 3
Synonyms	Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, Nr1i3, Car, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3
Immunogen	Recombinant protein corresponding to Mouse Nr1i3
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Cytoplasm
Predicted MW.	41 kDa
Observed MW.	41 kDa
Uniprot ID	O35627, Q9QUS1

Applications

Applications	Species	Dilution	Positive Sample
WB	Mouse, Rat	1: 500-1: 1000	liver
IHC/IF	Mouse, Rat	1: 500-1: 1000	hepatitis

Background

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription.

Images

	Western blot analysis of NR1I3 (GB111418) at dilution of 1: 500
	Immunohistochemistry of paraffin embedded mouse hepatitis using NR1I3 (GB111418) at dilution of 1: 500 (200x lens)
	Immunohistochemistry of paraffin embedded rat hepatitis using NR1I3 (GB111418) at dilution of 1: 500 (200x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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