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Anti -Polycystin 1/PC1 Rabbit pAb
價(jià)格：
在線咨詢
貨號：
KT011972
產(chǎn)品規(guī)格：
100ul
Applications：
WB
Species：
H
購買數(shù)量：
產(chǎn)品詳情
操作說明
注意事項(xiàng)
Product Information
|
Description |
Polycystin 1 rabbit polyclonal antibody |
|
Protein full name |
Polycystin-1 |
|
Synonyms |
PC1, Autosomal dominant polycystic kidney disease 1 protein, PKD1, PBP, PKD, PKD1, Polycystin 1 Precursor |
|
Immunogen |
Recombinant protein corresponding to Mouse Polycystin 1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
463 kDa |
|
Observed MW. |
>460 kDa |
|
Uniprot ID |
P98161 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human |
1: 500-1: 1000 |
HEK293, NIH/3t3, PC12, HCT116, SW480 |
Background
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Involved in renal tubulo genesis. Involved in fluid-flow mechano sensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene.
Images
|
Western blot analysis of Polycystin-1 (GB111019) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學(xué)科技園A401室