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Anti -Neurofibromin Rabbit pAb
價格：
在線咨詢
貨號：
KT011584
產品規(guī)格：
100ul
Applications：
WB/IHC/IF
Species：
H/M/R,H/M/R
購買數(shù)量：
產品詳情
操作說明
注意事項
Product Information
|
Description |
Neurofibromin rabbit polyclonal antibody |
|
Protein full name |
Neurofibromin |
|
Synonyms |
Neurofibromatosis-related protein NF-1, Nf1, Neurofibromin, neurofibromin 1, NFNS, VRNF, WSS |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Neurofibromin |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus |
|
Predicted MW. |
320 kDa |
|
Observed MW. |
320 kDa |
|
Uniprot ID |
P21359, Q04690, P97526 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
lung |
|
IHC/IF |
Human, Mouse, Rat |
1: 750-1: 4000 |
brain, breast cancer, colon, lung, ovary, Skeletal muscle, testis |
Background
Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity.
Images
|
|
Western blot analysis of Neurofibrmin-1 (GB111112) at dilution of 1: 500 |
|
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Immunohistochemistry of paraffin embedded mouse brain using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens) |
|
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Immunohistochemistry of paraffin embedded mouse colon using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded mouse lung using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat colon using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens) |
|
Immunohistochemistry of paraffin embedded rat lung using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens) |
|
Immunohistochemistry of paraffin embedded rat skeletal muscle using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens) |
|
Immunofluorescence of paraffin embedded human breast cancer using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens) |
|
Immunofluorescence of paraffin embedded mouse brain using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens) |
|
|
Immunofluorescence of paraffin embedded mouse ovary using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens) |
|
|
Immunofluorescence of paraffin embedded rat testis using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學科技園A401室