Anti -LYRIC/AEG1 Rabbit pAb

價格：在線咨詢

貨號：

KT011564

產品規(guī)格：

100 μL

Applications：

Species：

H,M,R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	LYRIC rabbit polyclonal antibody
Protein full name	Protein LYRIC
Synonyms	3D3/LYRIC, Metadherin, Mtdh, Lyric, Lysine-rich CEACAM1 co-isolated protein, Metastasis adhesion protein
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse LYRIC
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Cytoplasm, Cell Membrane
Predicted MW.	64 kDa
Observed MW.	75 kDa
Uniprot ID	Q86UE4, Q80WJ7, Q9Z1W6

Applications

Applications	Species	Dilution	Positive Sample
WB	Human, Mouse, Rat	1: 500-1: 1000	heart, brain

Background

LYRIC protein also known as astrocyte elevated gene-1 protein (AEG-1). It is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions. AEG-1 induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). AEG-1 acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.

Images

Western blot analysis of LYRIC (GB111005) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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