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Product Information
Description |
DKK2 rabbit polyclonal antibody |
Protein full name |
Dickkopf-related protein 2 |
Synonyms |
Dickkopf-2, Dickkopf related protein 2, DKK-2, DKK2, hDkk 2, mDkk-2 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse DKK2 |
Isotype |
IgG |
Purity |
Affinity purification |
Predicted MW. |
28 kDa |
Observed MW. |
28 kDa |
Uniprot ID |
Q9QYZ8 |
Applications
Applications |
Species |
Dilution |
Positive Sample |
WB |
Mouse |
1: 1000-1: 2000 |
kidney, heart, lung |
Background
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Images
Western blot analysis of DKK2 (GB113829) at dilution of 1: 2000 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).
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